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. 2013 May 4;13:225. doi: 10.1186/1471-2407-13-225

Table 1.

Percent distribution of selected characteristics at diagnosis in 1,204 women with invasive breast cancer

 
All women
Younger women
Older women
(ages 35–49 y)
(ages 50–64 y)
 
White
Black
Pa
White
Black
Pa
White
Black
Pa
  n=681 n=523   n=345 n=272   n=336 n=251  
Study site
 
 
0.01
 
 
0.07
 
 
0.09
 Los Angeles
66.7
73.2
 
64.9
71.7
 
68.5
74.9
 
 Detroit
33.3
26.8
 
35.1
28.3
 
31.6
25.1
 
Age at diagnosis, years
 
 
0.004
 
 
<0.001
 
 
 
 35-39
21.4
14.2
 
42.3
27.2
 
-
-
 
 40-44
15.9
19.5
 
31.3
37.5
 
-
-
 
 45-49
13.4
18.4
 
26.4
35.3
 
-
-
 
 50-54
18.7
17.6
 
-
-
 
37.8
36.7
0.42
 55-59
14.5
16.4
 
-
-
 
29.5
34.3
 
 60-64
16.2
14.0
 
-
-
 
32.7
29.1
 
ER status
 
 
<0.001
 
 
0.05
 
 
<0.001
 ER-
36.9
48.8
 
46.4
54.4
 
27.1
42.6
 
 ER+
63.1
51.2
 
53.6
45.6
 
72.9
57.4
 
PR status
 
 
<0.001
 
 
<0.001
 
 
<0.001
 PR-
38.5
52.4
 
42.6
54.0
 
34.2
50.6
 
 PR+
61.5
47.6
 
57.4
46.0
 
65.8
49.4
 
HER2 status
 
 
0.16
 
 
0.98
 
 
0.04
 HER2-
83.3
80.1
 
81.2
81.3
 
85.4
78.9
 
 HER2+
16.7
19.9
 
18.8
18.7
 
14.6
21.1
 
Subtypes defined by ER/PR/HER2
 
 
<0.001
 
 
0.12
 
 
<0.001
 TN
23.8
33.5
 
30.4
39.0
 
17.0
27.5
 
 Luminal A
59.5
46.7
 
50.7
42.3
 
68.5
51.4
 
 Luminal B
9.8
10.3
 
11.0
9.9
 
8.6
10.8
 
 HER2-enriched
6.9
9.6
 
7.8
8.8
 
6.0
10.4
 
p53 status
 
 
<0.001
 
 
 
 
 
0.003
 p53-
77.0
65.8
 
72.5
61.0
0.003
81.6
70.9
 
 p53+
23.0
34.2
 
27.5
39.0
 
18.4
29.1
 
Subtypes defined by ER/PR/HER2/p53
 
 
<0.001
 
 
0.03
 
 
<0.001
 TN/p53-
14.4
16.6
 
18.0
18.8
 
10.7
14.3
 
 TN/p53+
9.4
16.8
 
12.5
20.2
 
6.3
13.2
 
 Luminal A/p53-
49.9
37.7
 
41.5
31.3
 
58.6
44.6
 
 Luminal A/p53+
9.5
9.0
 
9.3
11.0
 
9.8
6.8
 
 Luminal B/p53-
8.1
6.0
 
8.4
5.2
 
7.7
6.8
 
 Luminal B/p53+
1.8
4.4
 
2.6
4.8
 
0.9
4.0
 
 HER2-enriched/p53-
4.6
5.5
 
4.6
5.9
 
4.5
5.2
 
 HER2-enriched/p53+
2.4
4.0
 
3.2
2.9
 
1.5
5.2
 
Stage
 
 
<0.001
 
 
0.007
 
 
0.001
 Localized
63.1
51.1
 
56.5
45.6
 
69.9
57.0
 
 Non-localized
36.9
49.0
 
43.5
54.4
 
30.1
43.0
 
Grade
 
 
<0.001
 
 
0.006
 
 
<0.001
 Low
12.5
8.6
 
9.6
6.6
 
15.5
10.8
 
 Intermediate
63.1
53.0
 
58.6
49.3
 
67.9
57.0
 
 High 24.4 38.4   31.9 44.1   16.7 32.3  

aP ascertained from Pearson χ2 test. Abbreviations: ER, estrogen receptor; PR, progesterone receptor; HER, human epidermal growth factor receptor; TN, triple negative. Note: TN = ER-/PR-/HER2-, Luminal A = ER+ or PR+ plus HER2-, Luminal B = ER+ or PR+ plus HER2+, HER2-enriched = ER-/PR-/HER2+.