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. 2013 May 8;8(5):e61788. doi: 10.1371/journal.pone.0061788

Figure 3. Triple negative breast cancers and the mesenchymal stem-like (MSL) subtype of triple negative breast cancers are associated with increased pro-angiogenic gene expression and decreased anti-angiogenic gene expression.

Figure 3

A–B, Principal component analysis (PCA) scores (A) and loadings (B) for VEGF- and semaphorin-related genes in all tumors. Gene names are only shown for probes whose loadings on the two principal components exceeded a radius of 0.2 from the origin. Circles denote genes whose names do not appear. Triple-negative (TN) samples project to lower values of tumor PC4a, corresponding to high VEGFA and low SEMA3 expression. C–D, PCA scores (C) and loadings (D) for VEGF- and semaphorin-related genes in only the TN samples. The MSL subtype projected to low values of TNBC PC2t, corresponding to up-regulation of VEGFC, SEMA3G, and SEMA5A and down-regulation of VEGFA.