Table 5. SMACv1.0 simple de novo outlier contigs from a genome-wide analysis of divergence with the zebra finch.
| Predicted Outlier Contig Genes and Proteins1 | Known Function or GWAS Trait Classification | References |
| EYA2, EPHB3, BCL6, NRP2, ALCAM | Neuronal Development | [118]–[120] |
| SATB2 | Neuron Specification | [121] |
| ALCAM, BCL6, NRP2, ALDH6A1, TP63, CUX1, ATXN1, | Neurological Disorders | [120], [122]–[132] |
| VIPR2, WHSC1, BRSK2, CLINT1, DUSP8, ANKFN1, PI4KA | ||
| ANKFN1, LPP, BOC | Human Developmental Anomalies | [133]–[135] |
| ALDH6A1 | Hippocampal and Cognitive Aging | [122] |
| UPF0632 Protein A | White Matter Integrity in Old Age | [136] |
| VPS52 | Brian Striatal Volume, Cognition | [136]–[138] |
| LDB2, DMXL2 | Susceptibility to Coronary Artery Disease | [139]–[140] |
| SLC38A1 | Cardiovascular-Left Ventricular Mass | [141] |
| ABCB8, RBM20, | Cardiomyopathy | [142]–[143] |
| FOXC1 | Embryonic Cardiovascular Development | [144] |
| VTI1A | Heart Ventricular Conduction | [96] |
| TTN | Heart Q-wave T-wave Interval Length | [97] |
| ZPLD1 | Cerebrovascular Developmental Disorders | [145] |
| FOXF2 | Developmental Disorders of the Genitalia | [146] |
| SATB2 | Osteogenic Differentiation, Regeneration | [147] |
| MAP3K4 | Myogenesis | [148] |
| DCT | Pigment Biosynthesis | [149] |
| VSX2 | Eye Development-Microphthalmia | [150] |
| EYA2 | Ocular Neural Pattern Development | [65] |
| SCFD2 | Optic Disc Size-Cup Area | [151] |
| SDF2L1 | Innate Immunity | [152] |
| MKX | Tendon Differentiation and Development | [153] |
| NGEF | Adiposity | [154] |
| NPY2R | Feeding Behavior, Oral Feeding Success | [155] |
| TCF7L2, Intergenic GPATCH2 and ESRRG, FOSL2, PPP1CB | Diabetes | [156]–[159] |
1
For outlier direction, see Table S14.