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. 2013 May 8;8(5):e64028. doi: 10.1371/journal.pone.0064028

Figure 1. The 53BP1 homolog in C. elegans, HSR-9 protein, accumulates in the nuclei of C. elegans germ cells in response to γ-rays.

Figure 1

(A) HSR-9 is the most similar of the predicted open reading frames in C. elegans to human 53BP1 in its C-terminal BRCT domains (27% amino acid identity) and N-terminus (21% amino acid identity). The regions controlling nuclear focus formation (Foci) and the Tudor domains are also conserved [22], [34]. (B) The deletion in hsr-9(ok759) is shown in blue in this representation of the gene, and the Mos1 insertion is in brown. The polypeptide fragment used for antibody production is indicated by the pink bar. (C) HSR-9 was immuno-localized to the nuclei of wild-type germ cells in the mitotically proliferating region of gonads 3 h after γ-ray (75 Gy) treatment. Scale bar, 10 µm.