Figure 1.
SIN-1 prolongs the atrial and ventricular action potential. (A) The peroxynitrite scavenger uric acid was used to evaluate specificity of SIN-1. Atrial action potentials were recorded at baseline, with uric acid and with uric acid + SIN-1. No statistical change in atrial APD90 was observed after co-superfusion. (B) SIN-1 prolongs the atrial action potential and (C) SIN-1 prolongs the action potential and decreases the phase 1 notch in ventricular myocytes.