Table 1.
Serum proteins co-eluted with IgG
| Protein Name | Accession Number |
|---|---|
| integrin alpha-9 precursor | gi|52485941 |
| disintegrin and metalloproteinase domain-containing protein 9 precursor * | gi|4501915 |
| neural cell adhesion molecule 2 precursor | gi|33519481 |
| SH3 and multiple ankyrin repeat domains protein 3 * | gi|122937241 |
| extended synaptotagmin-1 isoform 2 * | gi|14149680 |
| SLIT and NTRK-like protein 3 precursor | gi|40217820 |
| microtubule-actin cross-linking factor 1 isoform b | gi|33188443 |
| calmodulin-regulated spectrin-associated protein 2 | gi|44955929 |
| vesicle-associated membrane protein 7 isoform 3 * | gi|297747292 |
| synphilin-1 | gi|76563940 |
| huntingtin | gi|90903231 |
| cytoplasmic dynein 1 heavy chain 1 | gi|33350932 |
| dynein heavy chain 2, axonemal | gi|75677365 |
| dynein heavy chain 5, axonemal | gi|19115954 |
| dynein heavy chain 6, axonemal | gi|194353966 |
| dynein heavy chain 7, axonemal | gi|151301127 |
| dynein heavy chain 10, axonemal | gi|198442844 |
| ephrin type-A receptor 5 isoform a precursor | gi|221625401 |
| ephrin type-A receptor 8 isoform 1 precursor | gi|10140845 |
| ephrin type-A receptor 10 isofom 3 | gi|150456460 |
| V-type proton ATPase subunit B, brain isoform | gi|19913428 |
| Kv channel-interacting protein 2 isoform 2 | gi|27886670 |
| tax1-binding protein 1 isoform b * | gi|119943086 |
| serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform | gi|21361399 |
| adenylate cyclase type 8 | gi|4557257 |
| rho guanine nucleotide exchange factor 11 isoform 2 | gi|38026934 |
| activated CDC42 kinase 1 isoform 1 | gi|56549666 |
| pleckstrin homology domain-containing family A member 4 isoform 1 * | gi|238859651 |
| nuclear factor related to kappa-B-binding protein isoform 1 | gi|219802034 |
| paired box protein Pax-2 isoform a * | gi|34878699 |
| zinc finger protein 496 | gi|14249386 |
| zinc finger protein 561 * | gi|206725458 |
| zinc finger protein 611 isoform a | gi|239787080 |
| CREB-binding protein isoform b | gi|119943102 |
| protein argonaute-2 isoform 2 * | gi|257467482 |
| histone-lysine N-methyltransferase NSD3 isoform long * | gi|13699811 |
| E3 ubiquitin-protein ligase PDZRN3 * | gi|57529737 |
| E3 ubiquitin-protein ligase RBBP6 isoform 2 | gi|33620716 |
| 26S proteasome non-ATPase regulatory subunit 1 isoform 1 | gi|25777600 |
| apoptosis-inducing factor 1, mitochondrial isoform 4 * | gi|195927004 |
| baculoviral IAP repeat-containing protein 3 | gi|33946285 |
| baculoviral IAP repeat-containing protein 6 | gi|153792694 |
| protein S100-A8 | gi|21614544 |
| annexin A1 | gi|4502101 |
| NACHT, LRR and PYD domains-containing protein 2 isoform 1 * | gi|291463275 |
| complement C3 precursor | gi|115298678 |
| complement C5 preproprotein | gi|38016947 |
| complement component C8 alpha chain precursor | gi|4557389 |
| complement component C8 beta chain preproprotein | gi|4557391 |
| complement factor H-related protein 1 precursor * | gi|118442839 |
Potential biomarker candidates of glaucoma. Listed are fifty serum proteins detected by 2D-LC-MS/MS analysis of the glaucomatous serum IgG elutes, which are also known to be present in the glaucomatous human retina. All listed proteins were identified with high confidence (more than 99.0% probability assigned by the Protein Prophet algorithm) based on at least two identified peptides.
indicates methionine oxidation increased or detectable only in glaucomatous samples. This selected list of potential biomarker candidates awaits larger validation studies to establish their value as a clinical tool to determine diagnosis, prognosis, and/or treatment responses in glaucoma. This table has recently been published (Tezel et al., 2012b).