Table 2.
Summary of the apoptotic rates detected for each DLBCL cell line as result of the treatment with HhAntag alone and with the combination of IC20 doses of ABT-737 with increasing concentrations of HhAntag.
| Cell Type | Doses of “Hh- Antagonist” (µM) |
% of Apoptosis “Hh-Antagonist” Alone |
% of Apoptosis “Hh-Antagonist” + ABT-737 |
p-value |
|---|---|---|---|---|
| DOHH2 | 2.5 | 9.3 | 20.4 | 0.011 |
| 5.0 | 12.3 | 22 | 0.017 | |
| 7.5 | 16.2 | 40.4 | 0.009 | |
| SuDHL4 | 2.5 | 11.5 | 12.8 | 0.7 |
| 5.0 | 21.8 | 31.1 | 0.1 | |
| 7.5 | 34.5 | 49.5 | 0.119 | |
| HT | 2.5 | 12.8 | 25.4 | 0.008 |
| 5.0 | 14.7 | 48.9 | 0.002 | |
| 7.5 | 26.4 | 61.7 | 0.011 | |
| OCI-LY19 | 2.5 | 33.2 | 46 | 0.011 |
| 5.0 | 46 | 70.5 | 0.001 | |
| 7.5 | 55 | 82.3 | 0.002 | |
| TOLEDO | 2.5 | 27 | 45.4 | 0.001 |
| 5.0 | 33.4 | 66 | 0.002 | |
| 7.5 | 36.8 | 89.4 | 0.001 | |
| OCI-LY3 | 2.5 | 35.5 | 51.2 | 0.053 |
| 5.0 | 58.8 | 65.8 | 0.125 | |
| 7.5 | 73.5 | 77.1 | 0.280 | |
| OCI-LY10 | 1.0 | 12.2 | 15.0 | 0.246 |
| 2.5 | 34.1 | 55.7 | 0.015 | |
| 5.0 | 79.5 | 88.6 | 0.074 |