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. Author manuscript; available in PMC: 2014 May 15.
Published in final edited form as: Cancer. 2013 Feb 21;119(10):1792–1799. doi: 10.1002/cncr.27893

Table 1.

Genetic alterations and exposure-related characteristics among cases of thyroid cancer developed after the Chernobyl accident in Ukraine

Genetic Alteration Mutation
frequency
I-131 dose,
mean (Gy)
Age at
exposure,
mean (yr)
Age at
surgery,
mean (yr)
Time since
exposure,
mean (yr)
RET/PTC1 14 (22%) 1.04 6.4 23.6 16.9
RET/PTC3 8 (13%) 1.54 6.3 20.1 13.7
BRAF 9 (15%) 0.27 10.2 27.1 16.8
RAS * 5 (8%) 0.20 10.9 29.4 18.6
PAX8/PPARγ * 2 (3%) 0.62 12.2 25.8 13.5
No known mutation 25 (40%) 1.97 7.8 24.4 16.6
Total/overall 62 (100%) 1.27 8.1 24.6 16.5
*

One case was found to be positive for both NRAS mutation and PAX8/PPARγ rearrangement.