Table 3.

Selected strong (OR ≥ 2.0 or ≤ 0.5) genotype-phenotype associations relevant to a female patient of European ancestry

Gene	Selected* Phenotypes with Strong (OR ≥ 2.0 or ≤ 0.5) Association
ABCB1	Breast Cancer, Colorectal Cancer, Inflammatory Bowel Disease
ABCG2	Gout
CYP1A1	Breast Cancer, Colorectal Cancer, Coronary Artery Disease, Endometrial Cancer, Head and Neck Cancer, Leukemia, Lung Cancer, Ovarian Cancer, Psoriasis, Type 2 Diabetes
CYP1A2	Colorectal Cancer, Endometrial Cancer, Hypertension, Ovarian Cancer
CYP2C9	Mood Disorder
CYP2D6	Colorectal Cancer, Lung Cancer, Parkinson's Disease, Scleroderma
CYP2E1	Colorectal Cancer, Gastric Cancer, Head and Neck Cancer, Lung Cancer, Scleroderma
CYP3A4	Lung Cancer
CYP3A5	Hypertension
GSTM1	Alcoholic Pancreatitis, Asthma, Basal Cell or Squamous Cell Carcinoma, Breast Cancer, Esophageal Cancer, Head and Neck Cancer, Hypertension, Lung Cancer, Ovarian Cancer, Renal Cancer, Rheumatoid Arthritis, Urinary Tract Cancer
GSTP1	Breast Cancer, Colorectal Cancer, Gastric Cancer, Hodgkin's Lymphoma, Lung Cancer, Parkinson's Disease, Urinary Tract Cancer
GSTT1	Asthma, Breast Cancer, Colorectal Cancer, Coronary Artery Disease, Esophageal Cancer, Gastric Cancer, Head and Neck Cancer, Leukemia, Lung Cancer, Melanoma, Non-Hodgkin's Lymphoma, Renal Cancer, Urinary Tract Cancer
NAT1	Asthma, Lung Cancer
NAT2	Breast Cancer, Cervical Cancer, Endometriosis, Gastric Cancer, Head and Neck Cancer, Lung Cancer, Ovarian Cancer, Urinary Tract Cancer
SULT1A1	Breast Cancer, Colorectal Cancer, Endometrial Cancer, Gastric Cancer, Head and Neck Cancer, Urinary Tract Cancer
UGT1A1	Endometrial Cancer

^*Relatively minor or rare phenotypes omitted