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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Eur J Neurosci. 2013 Feb 7;37(9):1383–1393. doi: 10.1111/ejn.12144

Figure 3. Postsynaptic addition of PKA blockers suppress the effect of forskolin (FSK) effects on GABAergic transmission.

Figure 3

A, FSK action on GABAergic transmission was suppressed by a membrane-impermeable PKA inhibitor PKI (6–22) amide added to the postsynaptic neurons through the whole-cell patch pipette. FSK (20µM) was focally applied as indicated. B, The graph shows suppression of the modulatory action of FSK by PKI amide and H-89. In all cases, 20µM FSK was applied for 30 sec. Student t-test, * P< 0.05, ** P< 0.01, *** P< 0.001. Number of replicates: 50µM H-89 (n=3), 200µM PKI (n=4), 400µM PKI (n=4).