Figure 7.

Maximal donor cell engraftment in sheep occurs during the mid-to-later stages of the tolerance induction period. This period follows thymic demarcation and formation of the osteoblastic niche. Further, engraftment is durable as the engraftment kinetics are similar to that noted at 60 d post transplant supporting our contention that the graft is viewed by the recipient as self (see Figure 6)[2].