Table 2.
Comparison of factors between chronic hepatitis C patients with and without sustained virological response in the present study
|
Previous treatment |
||||||
|
(-) |
(+) |
|||||
| SVR | Non-SVR | P value1 | SVR | Non-SVR | P value1 | |
| Number of patients | 72 | 55 | 27 | 42 | ||
| Age (yr) | 54.6 ± 10.9 | 58.0 ± 10.3 | NS | 58.5 ± 9.9 | 59.3 ± 10.3 | NS |
| Gender (male/female) | 41/31 | 21/34 | 0.036 | 11/16 | 23/19 | NS |
| Body mass index (kg/m2) | 23.4 ± 3.2 | 23.3 ± 3.9 | NS | 23.6 ± 3.6 | 22.8 ± 2.6 | NS |
| LDL cholesterol (mg/dL) | 107 ± 52.3 | 102 ± 31.5 | NS | 100 ± 31.3 | 92.8 ± 26.7 | NS |
| ALT (IU/L) | 67.6 ± 42.0 | 77.8 ± 65.9 | NS | 52.9 ± 35.4 | 75.1 ± 54.0 | NS |
| Gamma-glutamyl transferase (IU/L) | 45.1 ± 43.1 | 69.8 ± 102 | NS | 50.2 ± 51.1 | 76.9 ± 88.0 | NS |
| Alpha-fetoprotein (ng/mL) | 8.8 ± 9.7 | 17.4 ± 43.1 | NS | 13.3 ± 26.3 | 32.6 ± 96.5 | NS |
| HCV RNA (log IU/mL) | 6.4 ± 0.7 | 6.6 ± 0.6 | NS | 6.3 ± 0.9 | 6.4 ± 0.6 | NS |
| White blood cells (/mL) | 5363 ± 1582 | 5015 ± 1423 | NS | 4561 ± 1175 | 4657 ± 1345 | NS |
| Neutrophils (/mL) | 2910 ± 1006 | 2546 ± 767 | NS | 2337 ± 813 | 2562 ± 1074 | NS |
| Hemoglobin (g/dL) | 14.2 ± 1.5 | 13.8 ± 1.4 | NS | 13.8 ± 1.1 | 13.7 ± 1.9 | NS |
| Platelets (× 104/mL) | 17.5 ± 4.9 | 15.3 ± 4.8 | 0.013 | 16.5 ± 4.9 | 15.0 ± 5.3 | NS |
| RVR (+/-) | 18/54 | 0/55 | < 0.001 | 7/20 | 0/42 | < 0.001 |
| EVR (+/-) | 56/16 | 10/45 | < 0.001 | 8/19 | 5/37 | < 0.001 |
Values are expressed as mean ± SD.
1
P value indicates those between two groups with and without Sustained virological response (SVR) by Student’s t test or χ2 test. NS: Not significant; LDL: Low-density lipoprotein; ALT: Alanine aminotransferase; HCV: Hepatitis C virus; RVR: Rapid virological response; EVR: Early virological response.