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. Author manuscript; available in PMC: 2014 Apr 2.
Published in final edited form as: Anal Chem. 2013 Mar 18;85(7):3621–3628. doi: 10.1021/ac303441n

Figure 4.

Figure 4

Apparent conductance measurements recorded with P-SICM (a-b) Histograms of conductance measurements obtained over cell bodies (hatch) and over the cell junctions (solid) on (a) MDCKII-WT and (b) MDCKII-C2 cell monolayers. (c) Average values of local conductance measured for MDCKII-WT (red) and MDCKII-C2 (blue). Statistical significance (p < 0.001) between para- and transcellular conductance measured over the cell junction (CJ) and over the cell body (CB) was determined for both MDCKII-WT and MDCKII-C2 monolayers. (d) Histogram of conductances recorded over CJs for MDCKII-WT (red) presents a broader distribution with a larger mean value, as compared to that of MDCKII-C2 (blue). These observations indicate that claudin-2 functions to regulate the epithelial permeability through paracellular pathways.