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Cross-sectional association between plasma homocysteine and Mini-Mental State Examination (MMSE) performance at 5 successive examinations of the Framingham Original Cohort (N = 541). Examinations occurred 2 y apart. Plotted β coefficients give the decrease in the MMSE score per micromole per liter increase in homocysteine. Results are adjusted for age, sex, education, smoking status, serum creatinine, and body mass index.
