Table 1.

Known VKD proteins are involved in many physiologies¹

VKD proteins involved in hemostasis	VKD proteins with nonhemostatic function
Prothrombin	Matrix Gla protein
Factor VII	Osteocalcin
Factor IX	TMG 1
Factor X	TMG 2
Protein Z	TMG 3
Protein S	TMG 4
Protein C	Gla-rich protein
	Gas6
	Periostin

¹Proteins C and S have both hemostatic and nonhemostatic function. Gla, γ-carboxyglutamate; TMG, transmembrane Gla protein; VKD, vitamin K–dependent.