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. 2012 Mar 2;3(2):174–181. doi: 10.3945/an.111.001685

Figure 1.

Figure 1

Schematic representation of vertebrate GRP gene and protein structures (A) and mouse transcript variants (B). In gene structure, exons (limited to coding sequence) are represented by white boxes/Arabic numbers and introns by black lines/Roman numbers; phase of intron insertion is indicated in gray triangles. In protein structure, Gla residues are indicated by blue dots and Gla domain is represented by a blue box; SNPs are indicated by asterisks and those affecting important protein domains by letters a, b, c, d, and e (Table 4); red and yellow triangles indicate AXXF and RXXR proteolytic cleavage sites, respectively; γ indicates the docking site for γ-glutamyl carboxylase. In transcript variants, mRNA structure (limited to coding sequence) of the 4 variants (F1–4) is indicated on the left side and peptide structure on the right side. Length of each peptide is indicated after the Gla domain. Gla, γ-carboxy glutamate; MP, mature peptide; PP, propeptide; SNP, single-nucleotide polymorphism; SP, signal peptide.