Table 5.
Sites of human GRP gene expression and protein accumulation in pathological conditions
| Tissue | Origin | Cell type expressing GRP | Detection method1 | Reference |
| Dermatomyositis with calcinosis | Human | Human skin with calcifications | IHC | (13) |
| Pseudoxanthoma elasticum | Human | Human skin with calcifications | IHC | (13) |
| Scars | Human | Calcified scar tissue | IHC | (13) |
| Chronic kidney disease | Human | Arteries with calcifications | IHC | (13) |
| OA model with surgically induced destabilization of medial meniscus | Mouse | Increase in knee joint tissue of old (12 mo) vs. young (12 wk) animals | Microarray | (21) |
1
IHC, immunohistochemistry; OA, osteoarthritis.