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. Author manuscript; available in PMC: 2014 Mar 28.
Published in final edited form as: Cell. 2013 Mar 28;153(1):38–55. doi: 10.1016/j.cell.2013.03.008

Figure 1. Representative Epigenetic States.

Figure 1

Examples of representative epigenetic states are shown for several typical categories of genes and in different cellular contexts. A. CpG-poor promoters are often tissue-specific and/or reside in inducible genes which can be readily turned on or off. Transcription factor (TF) binding at regulatory elements and the promoter initiates nuclear depleted regions (NDR). B. Many genes with CpG island promoters are constitutively expressed housekeeping genes. C. Some genes with CpG island promoters, such as transcription factor master regulators of differentiation and development are repressed by the Polycomb complexes in stem cells and kept in a bivalent state with both active and repressive marks. D. Polycomb targets in stem cells are predisposed to cancer-specific promoter hypermethylation.