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. 2013 May 9;3:1809. doi: 10.1038/srep01809

Figure 2. TNF from myeloid cells regulates cellular recruitment for granuloma formation but is dispensable for initiation and maintenance of granuloma structure.

Figure 2

(A; B) WT (black), M-TNF−/− (grey), and TNF−/− (clear) mice were infected with M. tuberculosis H37Rv as described under “Materials and Methods” and lung weights (A) and cell numbers (B) assessed at the indicated time points. Data represent the mean ± SD of 5 mice per time point and one of three independent experiments. * = p < 0.05 (WT versus M-TNF−/− mice), # = p < 0.05 (WT versus TNF−/− mice.), ϕ = p < 0.05 (M-TNF−/− versus TNF−/− mice). (C–D). Macroscopic lung pathology (C) in WT, M-TNF−/− and TNF−/− mice at 28 days post infection (one of three independent experiments; n = 5 mice/strain). Low magnification (20×) of pulmonary granulomas at (i) 28 days and (ii) 166 days postinfection after haemotoxylin and eosin staining (D). Arrows indicate granulomatous structures and X indicates necrosis. The results represent one of 5 similar experiments.