Table.
PD with Pain (n=269) | PD without Pain (n=632) | p value | Multivariate analysis | ||
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No. (%) | No. (%) | OR (95%CI) | p value | ||
Age at enrollment (vs. <65 years) | 128 (47.6) | 274 (43.4) | 0.37 | Reference | 0.46 |
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65–74 years | 92 (34.2) | 220 (34.8) | 0.88 (0.63–1.23) | ||
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≥75 years | 49 (18.2) | 135 (21.8) | 0.78 (0.52–1.17) | ||
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Male, n (%) | 151 (56.1) | 411 (65.0) | 0.01 | 0.74 (0.54–1.01) | 0.06 |
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Education, years (vs 0–6) | 54 (20.1) | 150 (23.7) | 0.48 | Reference | 0.13 |
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7–12 | 125 (46.5) | 277 (43.8) | 1.39 (0.93–2.09) | ||
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≥13 | 90 (33.5) | 205 (32.4) | 1.54 (1.00–2.37) | ||
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PD duration, years (vs <5) | 151 (56.1) | 400 (63.3) | 0.10 | Reference | 0.51 |
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5–9 | 82 (30.5) | 153 (24.2) | 1.17 (0.82–1.66) | ||
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≥10 | 36 (13.4) | 79 (12.5) | 0.89 (0.55–1.45) | ||
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HY stage (vs stage I) | 44 (20.4) | 129 (16.4) | 0.01 | ||
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stage II | 159 (63.5) | 401 (59.1) | |||
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stage III | 66 (16.1) | 102 (24.5) | |||
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L-dopa use | 38 (14.1) | 126 (19.9) | 0.04 | Reference | 0.12 |
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Yes | 231 (85.9) | 506 (80.1) | 1.40 (0.91–2.15) | ||
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Motor fluctuation (vs no) | 218 (81.0) | 544 (86.4) | 0.26 | Reference | 0.75 |
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Yes | 51 (19.0) | 86 (13.6) | 1.08 (0.69–1.68) | ||
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Dyskinesias (vs no) | 135 (87.4) | 603 (95.4) | <0.001 | Reference | <0.001 |
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Yes | 34 (12.6) | 29 (4.6) | 2.66 (1.50–4.73) | ||
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Depression (vs no) | 44 (79.2) | 46 (91.5) | <0.001 | Reference | <.0001 |
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Yes | 56 (20.8) | 54 (8.5) | 2.88 (1.87–4.44) |
HY stage was not included in the multivariate analysis due to colinearity. When HY stage, but not PD duration, was included in the multivariate logistic regression model, the OR comparing higher HY stage with stage I was 1.11 (95%CI 0.74–1.66) for stage II, 1.59 (95%CI 0.95–2.68) for stage III