. Author manuscript; available in PMC: 2014 May 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2013 May;22(5):756–764. doi: 10.1158/1055-9965.EPI-12-1325

Table 2.

Effects of 16 Weeks of Aerobic Exercise on Estrogen Metabolism of WISER participants

	Baseline Geometric Mean (95% CI)	P-value for Baseline Differences	Follow Up Geometric Mean (95% CI)	P-value for Differences in Mean Change
*Estrone, E₁ (nmol/day)*
Exercisers	23.1 (19.0 – 28.2)	0.586	23.0 (18.9 – 28.0)	0.042
Controls	25.0 (20.3 – 30.8)		23.0 (18.8 – 28.2) ^a
*Estradiol, E₂ (nmol/day)*
Exercisers	7.8 (6.8 – 8.8)	0.786	8.3 (7.2 – 9.5)	0.725
Controls	8.0 (7.0 – 9.1)		8.0 (7.2 – 9.2)
*Estriol, E₃ (nmol/day)*
Exercisers	21.3 (16.5 – 27.4)	0.963	18.6 (14.4 – 24.2)	0.715
Controls	21.1 (16.2 – 27.5)		21.0 (16.0 – 27.5)
*16α-OHE₁ (nmol/day)*
Exercisers	2.9 (2.3 – 3.7)	0.303	2.6 (2.1 – 3.4)	0.971
Controls	2.5 (1.9 – 3.1)		2.5 (1.9 – 3.2)
*2- OHE₁ (nmol/day)*
Exercisers	39.3 (33.7 – 45.8)	0.084	44.2 (38.4 – 50.8)	0.098
Control	47.6 (40.5 – 55.8)		45.5 (39.3 – 52.6)
*4- OHE₁ (nmol/day)*
Exercisers	2.3 (2.1 – 2.7)	0.647	2.4 (2.1 – 2.7)	0.362
Controls	2.4 (2.1 – 2.8)		2.4 (2.1 – 2.7)
*2-OHE₂ (nmol/day)*
Exercisers	3.4 (2.4 – 5.0)	0.209	3.5 (2.4 – 5.1)	0.194
Controls	2.5 (1.7 – 3.6)		2.9 (1.9 – 4.2)
*4-OHE₂ (nmol/day)*
Exercisers	0.7 (0.4 – 1.0)	0.767	0.8 (0.5 – 1.3)	0.898
Controls	0.7 (0.5 – 1.2)		0.5 (0.3 – 0.8)
*2-MeOE₁ (nmol/day)*
Exercisers	8.2 (6.5 – 10.4)	0.312	9.3 (7.4 – 11.8)	0406
Controls	6.9 (5.4 – 8.8)		8.6 (6.8 – 10.9)
*4-MeOE₁ (nmol/day)*
Exercisers	1.9 (1.4 – 2.6)	0.562	1.7 (1.2 – 2.4)	0.488
Controls	2.2 (1.6 – 3.0)		1.5 (1.1 – 2.1)
*2-MeOE₂ (nmol/day)*
Exercisers	7.1 (5.4 – 9.3)	0.269	7.0 (5.4 – 9.1)	0.556
Controls	5.8 (4.3 – 7.6)		6.6 (5.1 – 8.7)
*4-MeOE₂ (nmol/day)*
Exercisers	1.6 (1.2 – 2.3)	0.254	1.5 (1.0 – 2.1)	0.552
Controls	1.2 (0.9 – 1.8)		0.9 (0.7 – 1.4)
*2-OHE₁/16α-OHE₁*
Exercisers	13.4 (10.4 – 17.2)	0.044	16.8 (13.1 – 21.4) ^b	0.045
Controls	19.3 (14.8 – 25.1)		18.5 (14.3 – 24.0)
*2-OHE₁/4-OHE₁*
Exercisers	16.8 (14.8 – 19.0)	0.104	18.7 (16.8 – 20.9)	0.123
Controls	19.5 (17.1 – 22.2)		18.9 (16.9 – 21.2)

NOTE: Values are age- and BMI-adjusted geometric means (95% CI). Follow-up and mean change from baseline comparisons in 2-OHE₁ and 2-OHE₁/16α-OHE₁ were additionally adjusted for baseline values.

Within-group differences:

P-value = 0.030,

P-value = 0.043