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Heterodimeric structure of MUC1 mucin glycoprotein. A detergent lysate of AGS human gastric epithelial cells was resolved on denaturing SDS-PAGE gels to separate the large molecular weight MUC1 extracellular (EC) region and the smaller cytoplasmic tail (CT) region. The separated proteins were probed on immunoblots with antibodies specific for the MUC1 EC and CT regions.
