FIGURE 4.

LEC activation during novel object-context recognition (Experiment 1). (A) c-Fos expression in VIE portion of LEC was significantly greater in the novel object-context recognition group (OCR) relative to the multiple context control (MCC) and the single context control (SCC). A further significant increase in c-fos expression in VIE was found in the MCC versus the SCC. Photographs show examples of c-fos expression from VIE of animals in the different conditions. (B) Discrimination of the novel versus familiar object-context association was correlated with level of c-fos expression in VIE in the OCR group (P = 0.049). (C) Mean total exploration of objects in the test phase did not differ across the three groups.