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. Author manuscript; available in PMC: 2013 Jul 15.
Published in final edited form as: Free Radic Biol Med. 2012 Apr 25;53(2):337–346. doi: 10.1016/j.freeradbiomed.2012.04.014

Figure 1. The temporal progression of tissue hypoxia in lung after radiation.

Figure 1

Tissue hypoxia is first noticeable around three days (CAIX, Pimonidazole) post-radiation and progressively increases throughout the follow-up period (6 months). At six weeks, the first histopathologic lesions are seen (H&E). These are generally focal in nature and are characterized by thickening of the alveoli wall and increased inflammatory cell infiltrate. By six months, tissue damage had considerably worsened and a greater number of focal lesions were observed. Error bars represent 100 µm.