Table 4.
Relationship between biomarker expression in UK and Nigerian tumours expressing KI-67.
| Variables | KI-67 positive expression | |||
|---|---|---|---|---|
| Nigeria (%) | UK (%) | χ 2 value | P value | |
| BRCA1 | ||||
| Negative | 143 (80.8) | 31 (21.5) | 112.34 | <0.001 |
| Positive | 34 (19.2) | 113 (78.5) | ||
| Bcl-2 | ||||
| Negative | 101 (57.4) | 53 (37.6) | 13.15 | <0.001 |
| Positive | 75 (42.6) | 88 (62.4) | ||
| CK5/6 | ||||
| Negative | 108 (58.7) | 137 (84.6) | 27.90 | <0.001 |
| Positive | 76 (41.3) | 25 (15.4) | ||
| CK14 | ||||
| Negative | 97 (58.8) | 148 (90.8) | 44.5 | <0.001 |
| Positive | 68 (41.2) | 15 (9.2) | ||
| ER | ||||
| Negative | 169 (84.5) | 45 (28.0) | 118.17 | <0.001 |
| Positive | 31 (15.5) | 116 (72.0) | ||
| EGFR | ||||
| Negative | 119 (66.5) | 123 (80.4) | 8.08 | 0.003 |
| Positive | 60 (33.5) | 30 (19.6) | ||
| E-cadherin | ||||
| Negative | 119 (73.5) | 65 (40.1) | 36.7 | <0.001 |
| Positive | 43 (26.5) | 97 (59.9) | ||
| HER-2 | ||||
| Negative | 148 (81.8) | 140 (87.5) | 2.13 | 0.14 |
| Positive | 33 (18.2) | 20 (12.5) | ||
| PgR | ||||
| Negative | 126 (79.7) | 68 (41.7) | 48.53 | <0.001 |
| Positive | 32 (20.3) | 95 (58.3) | ||
| p27 | ||||
| Negative | 131 (68.9) | 45 (46.4) | 13.77 | <0.001 |
| Positive | 59 (31.1) | 52 (53.6) | ||
| p21 | ||||
| Negative | 152 (83.1) | 65 (61.9) | 16.07 | <0.001 |
| Positive | 31 (16.9) | 40 (38.1) | ||
| p53 | ||||
| Negative | 1 (1.0) | 10 (14.7) | 13.11 | <0.001 |
| Positive | 104 (99.0) | 58 (85.3) | ||
| P-cadherin | ||||
| Negative | 81 (41.5) | 66 (44.9) | 0.38 | 0.54 |
| Positive | 114 (58.5) | 81 (55.1) | ||
| Triple negative | ||||
| No | 68 (45.6) | 128 (79.0) | 37.10 | <0.001 |
| Yes | 81 (54.4) | 34 (21.0) | ||
| Classification | ||||
| Basal | 56 (49.1) | 15 (10.2) | 149.02 | <0.001 |
| HER-2 | 26 (22.8) | 9 (6.2) | ||
| Luminal A | 27 (23.7) | 113 (77.4) | ||
| Luminal B | 5 (4.4) | 9 (6.2) | ||