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. Author manuscript; available in PMC: 2013 May 9.
Published in final edited form as: Biochem Biophys Res Commun. 2010 Jan 12;392(2):207–211. doi: 10.1016/j.bbrc.2010.01.016

Fig. 3.

Fig. 3

More islet cells were protected against STZ-induced apoptosis in S1P2−/− mice. Mice were injected with a high dose of STZ (100 mg/kg for 1 day) and apoptotic β-cells were identified by immunostaining (A) TUNEL-positive apoptotic β-cells in pancreatic sections obtained from WT and S1P2−/− mice. Bars: 50 μm. (B) Numbers of apoptotic cells per islet area (nm2) of WT and S1P2−/− mice (n = 10 each). The difference is significant (*P < 0.0001).