Table 3.
Anthropometric, HOMA index, and biochemical characteristics of subjects with different groups of genotype of the Leu162Val PPARα and Pro12Ala PPARγ2 polymorphisms.
| Parameters | Pro12Ala PPARγ2 | Leu162Val PPARα | ||||
|---|---|---|---|---|---|---|
| P/P (n = 369) |
X/A (n =153) |
P | L/L (n = 441) |
X/V (n = 81) |
P | |
| Age (years) | 41 (29–53) | 38 (28–49) | 0.088 | 39 (29–53) | 38 (29–48) | 0.177 |
| SBP (mmHg) | 125 (120–140) |
125 (120–135) |
0.102 | 125 (120–140) |
130 (120–135) |
0.854 |
| DBP (mmHg) | 80 (80–85) | 80 (80–85) | 0.127 | 80 (80–85) | 80 (80–85) | 0.465 |
| BMI (kg/m2) | 26.4 (24.4–28.3) |
25.6 (24.1–27.9) |
0.108 | 25.9 (24.3–28.2) |
26.6 (24.4–29.1) |
0.201 |
| WC (cm) | 93.0 (85.0–98.0) |
93.0 (81.5–97) |
0.404 | 93.0 (83.0–97.0) |
94.0 (86.5–98.5) |
0.076 |
| TG (mmol/L) | 1.51 ± 0.71 | 1.43 ± 0.76 | 0.186 | 1.50 ± 0.72 | 1.44 ± 0.72 | 0.497 |
| TC (mmol/L) | 4.73 (4.19–5.49) |
4.71 (4.11–5.27) |
0.271 | 4.72 (4.19–5.45) |
4.71 (4.12–5.41) |
0.526 |
| cLDL (mmol/L) | 3.09 (2.61–3.71) |
3.00 (2.62–3.67) |
0.513 | 3.07 (2.62–3.73) |
3.09 (2.57–3.63) |
0.410 |
| cHDL (mmol/L) | 1.12 (0.88–1.27) |
1.09 (0.90–1.34) |
0.368 | 1.11 (0.88–1.29) |
1.12 (0.92–1.33) |
0.475 |
| FPG (mmol/L) | 6.14 ± 1.77 | 5.45 ± 1.57 | <0.001 | 6.05 ± 1.79 | 5.36 ± 1.30 | 0.001 |
| FPI (mIU/L) | 9.83 (7.12–12.88) |
7.85 (6.16–11.22) |
<0.001 | 9.23 (6.92–12.83) |
8.91 (6.65–11.95) |
0.139 |
| HOMA-β% | 86 (64–100) |
95 (82–105) |
<0.001 | 88 (67–99) |
95 (80–119) |
<0.001 |
| HOMA-S% | 77 (54–109) |
102 (68–126) |
<0.001 | 80 (55–112) |
85 (62–118) |
0.043 |
| HOMA-IR | 1.3 (0.9–1.8) | 1.0 (0.8–1.5) | <0.001 | 1.2 (0.9–1.8) | 1.2 (0.9–1.6) | 0.067 |
| Cr (μmol/L) | 102.1 ± 45.8 | 92.5 ± 25.2 | 0.016 | 99.6 ± 41.6 | 97.9 ± 38.2 | 0.749 |
| Urea (mmol/L) | 6.45 ± 4.33 | 5.17 ± 2.34 | 0.001 | 6.29 ± 4.13 | 4.89 ± 1.83 | 0.003 |
| UA (μmol/L) | 307 (248–385) |
292 (234–350) |
0.036 | 306 (247–382) |
292 (233–341) |
0.042 |
| GFR (mL/min) | 89.5 (72.7–105.1) |
93.8 (71.6–111.3) |
0.004 | 89.0 (71.5–104.9) |
102.6 (76.1–113.5) |
0.002 |
P: Pro; A: Ala; L: Leu; V: Val; X/A: Pro/Ala and Ala/Ala; X/V: Leu/Val and Val/Val.
SBP: systolic blood pressure, DBP: diastolic blood pressure; BMI: body mass index; WC: waist circumference; TG: triglycerides; TC: total cholesterol; cHDL: high density lipoprotein cholesterol; cLDL: low density lipoprotein cholesterol; FPG: fasting plasma glucose; FPI: fasting plasma insulin; HOMA-β%: % β-cell function; HOMA-S%: % cell insulin sensitivity; HOMA-IR: insulin resistance; Cr: creatinine; UA: uric acid; GFR: glomerular filtration rate.