Table 5.
Comparison of anthropometric, HOMA index, and biochemical characteristics of subjects between different groups of Leu162Val PPARα genotypes in two subdivided groups according to metabolic syndrome.
| Parameters | SM− | SM+ | ||||
|---|---|---|---|---|---|---|
| Leu162Val PPARα | Leu162Val PPARα | |||||
| L/L (n = 213 ) |
X/V (n = 51) |
P | L/L (n = 228 ) |
X/V (n = 30) |
P | |
| Age (years) | 42 (29–52) | 38 (32–49) | 0.566 | 39 (29–56) | 36 (29–45) | 0.898 |
| SBP (mmHg) | 120 (115–120) |
120 (120–130) |
0.073 | 140 (130–150) |
135 (130–150) |
0.300 |
| DBP (mmHg) | 80 (75–80) | 80 (75–80) | 0.260 | 85 (80–90) | 85 (80–90) | 0.090 |
| BMI (kg/m2) | 24.5 (23.7–25.8) |
25.0 (23.9–28.1) |
0.172 | 27.7 (26.4–29.4) |
27.6 (26.5–29.4) |
0.400 |
| WC (cm) | 86 (79–93) |
93 (84–97) |
0.658 | 96 (92–99) |
96 (93–100) |
0.615 |
| TG (mmol/L) | 1.06 ± 0.44 | 1.09 ± 0.42 | 0.691 | 1.90 ± 0.70 | 2.02 ± 0.77 | 0.382 |
| TC (mmol/L) | 4.51 (4.14–4.93) |
4.53 (3.90–5.06) |
0.659 | 5.15 (4.22–5.78) |
5.12 (4.23–5.78) |
0.330 |
| cLDL (mmol/L) | 2.92 (2.52–3.31) |
2.97 (2.31–3.40) |
0.717 | 3.42 (2.76–4.03) |
3.30 (2.83–3.85) |
0.351 |
| cHDL (mmol/L) | 1.19 (1.10–1.46) |
1.16 (1.04–1.39) |
0.777 | 0.90 (0.79–1.14) |
0.95 (0.82–1.28) |
0.935 |
| FPG (mmol/L) | 4.94 ± 0.96 | 4.96 ± 0.88 | 0.846 | 7.08 ± 1.76 | 6.02 ± 1.60 | 0.002 |
| FPI (mIU/L) | 7.06 (5.86–8.25) |
7.48 (6.17–10.04) |
0.626 | 12.77 (10.09–13.25) |
11.26 (7.85–13.03) |
0.879 |
| HOMA-β% | 97 (88–105) |
100 (86–121) |
0.283 | 69 (52–93) |
85 (66–106) |
0.219 |
| HOMA-S% | 111 (95–134) |
103 (75–126) |
0.602 | 56 (53–73) |
64 (56–99) |
0.564 |
| HOMA-IR | 0.9 (0.8–1.1) | 1.0 (0.8–1.3) | 0.761 | 1.8 (1.4–1.9) | 1.6 (1.0–1.8) | 0.457 |
| Cr (μmol/L) | 86.3 ± 32.6 | 92.3 ± 22.5 | 0.216 | 111.9 ± 45.2 | 107.6 ± 54.7 | 0.631 |
| Urea (mmol/L) | 4.55 ± 2.87 | 4.12 ± 1.17 | 0.303 | 7.92 ± 4.46 | 6.02 ± 2.01 | 0.039 |
| UA (μmol/L) | 268 (206–313) |
250 (223–302) |
0.752 | 358 (285–433) |
348 (288–398) |
0.847 |
| GFR (mL/min) | 91.7 (79.4–105.8) |
99.1 (71.6–109.4) |
0.302 | 84.5 (60.4–104.7) |
108.8 (82.1–124.5) |
0.679 |
L, Leu; V, Val; X/V: Leu/Val and Val/Val.
SBP: systolic blood pressure, DBP: diastolic blood pressure; BMI: body mass index; WC: waist circumference; TG: triglycerides; TC: total cholesterol; cHDL: high density lipoprotein cholesterol; cLDL: low density lipoprotein cholesterol; FPG: fasting plasma glucose; FPI: fasting plasma insulin; HOMA-β%: % β-cell function; HOMA-S%: % cell insulin sensitivity; HOMA-IR: insulin resistance; Cr: creatinine; UA: uric acid; GFR: glomerular filtration rate.