Table 6.
Comparison of anthropometric, HOMA index, and biochemical characteristics of subjects between different groups of Pro12Ala PPARγ2 genotypes in two subdivided groups according to age.
| Parameters | Age < 60 years | Age ≥ 60 years | ||||
|---|---|---|---|---|---|---|
| Pro12Ala PPARγ2 | Pro12Ala PPARγ2 | |||||
| P/P (n = 289) |
X/A (n = 125) |
P | P/P (n = 80) |
X/A (n = 28) |
P | |
| Age (years) | 36 (29–46) | 35 (28–41) | 0.094 | 62 (59–66) | 64 (59–69) | 0.287 |
| SBP (mmHg) | 125 (120–140) |
125 (120–130) |
0.110 | 130 (120–140) |
130 (120–140) |
0.845 |
| DBP (mmHg) | 80 (80–85) | 80 (80–80) | 0.065 | 80 (80–85) | 80 (75–90) | 0.709 |
| BMI (kg/m2) | 26.0 (24.3–28.3) |
25.4 (24.2–27.9) |
0.276 | 26.9 (24.7–27.8) |
25.9 (23.7–28.1) |
0.237 |
| WC (cm) | 93.0 (84.0–98.0) |
93.0 (82.5–97) |
0.568 | 93.0 (86.0–98.0) |
91.0 (79.0–97.5) |
0.448 |
| TG (mmol/L) | 1.48 ± 0.71 | 1.44 ± 0.78 | 0.577 | 1.63 ± 0.70 | 1.34 ± 0.67 | 0.058 |
| TC (mmol/L) | 4.68 (4.11–5.45) |
4.68 (4.10–5.25) |
0.665 | 5.03 (4.46–5.68) |
4.74 (4.10–5.57) |
0.185 |
| cLDL (mmol/L) | 3.09 (2.61–3.71) |
3.00 (2.54–3.66) |
0.918 | 3.31 (2.92–3.84) |
3.09 (2.82–3.84) |
0.308 |
| cHDL (mmol/L) | 1.13 (0.88–1.28) |
1.13 (0.91–1.34) |
0.425 | 1.03 (0.88–1.24) |
1.05 (0.87–1.41) |
0.596 |
| FPG (mmol/L) | 6.08 ± 1.75 | 5.42 ± 1.49 | <0.001 | 6.36 ± 1.84 | 5.58 ± 1.91 | 0.057 |
| FPI (mIU/L) | 9.74 (7.12–12.88) |
7.92 (6.18–11.09) |
<0.001 | 10.47 (7.30–12.89) |
7.52 (6.01–11.49) |
0.049 |
| HOMA-β% | 88 (66–101) |
96 (82–106) |
0.002 | 81 (55–99) |
91 (82–103) |
0.056 |
| HOMA-S% | 79 (55–110) |
102 (68–126) |
<0.001 | 73 (53–104) |
103 (67–131) |
0.030 |
| HOMA-IR | 1.3 (0.9–1.8) | 1.0 (0.8–1.5) | <0.001 | 1.4 (1.0–1.9) | 1.0 (0.8–1.5) | 0.038 |
| Cr (μmol/L) | 100.0 ± 45.4 | 89.3 ± 19.7 | 0.012 | 109.6± 47.1 | 107.0 ± 39.0 | 0.377 |
| Urea (mmol/L) | 6.15 ± 4.05 | 5.05 ± 2.19 | 0.005 | 7.54 ± 5.08 | 5.70 ± 2.90 | 0.073 |
| UA (μmol/L) | 302 (247–387) |
294 (241–353) |
0.143 | 319 (248–383) |
279 (211–347) |
0.083 |
| GFR (mL/min) | 93.5 (83.3–109.4) |
101.9 (85.2–112.9) |
0.054 | 66.4 (48.9–77.6) |
60.2 (52.7–71.6) |
0.002 |
P: Pro; A: Ala; L: Leu; X/A: Pro/Ala and Ala/Ala.
SBP: systolic blood pressure, DBP: diastolic blood pressure; BMI: body mass index; WC: waist circumference; TG: triglycerides; TC: total cholesterol; cHDL: high density lipoprotein cholesterol; cLDL: low density lipoprotein cholesterol; FPG: fasting plasma glucose; FPI: fasting plasma insulin; HOMA-β%: % β-cell function; HOMA-S%: % cell insulin sensitivity; HOMA-IR: insulin resistance; Cr: creatinine; UA: uric acid; GFR: glomerular filtration rate.