Table 7.
Comparison of anthropometric, HOMA index, and biochemical characteristics of subjects between different groups of Leu162Val PPARα genotypes in two subdivided groups according to age.
| Parameters | Age < 60 years | Age ≥ 60 years | ||||
|---|---|---|---|---|---|---|
| Leu162Val PPARα | Leu162Val PPARα | |||||
| L/L (n = 345) |
X/V (n = 69) |
P | L/L (n = 96) |
X/V (n = 12) |
P | |
| Age (years) | 36 (28–45) | 36 (28–43) | 0.622 | 62 (60–67) | 62 (60–69) | 0.957 |
| SBP (mmHg) | 125 (120–140) |
130 (120–135) |
0.389 | 130 (120–140) |
125 (120–135) |
0.178 |
| DBP (mmHg) | 80 (80–85) | 80 (80–85) | 0.859 | 80 (80–85) | 80 (75–80) | 0.159 |
| BMI (kg/m2) | 25.7 (24.3–28.3) |
26.6 (24.3–29.4) |
0.147 | 26.9 (24.5–27.7) |
26.8 (24.5–28.6) |
0.965 |
| WC (cm) | 93.0 (82.0–97.0) |
94.0 (87.5–98.5) |
0.060 | 93.0 (85.5–97.5) |
92.0 (81.5–98.5) |
0.934 |
| TG (mmol/L) | 1.47 ± 0.73 | 1.47 ± 0.73 | 0.985 | 1.59 ± 0.69 | 1.24 ± 0.72 | 0.095 |
| TC (mmol/L) | 4.73 (4.19–5.49) |
4.72 (4.14–5.42) |
0.870 | 4.89 (4.48–5.68) |
4.63 (3.95–5.27) |
0.127 |
| cLDL (mmol/L) | 3.09 (2.61–3.71) |
3.17 (2.57–3.64) |
0.847 | 3.31 (2.91–3.84) |
3.06 (2.39–3.79) |
0.261 |
| cHDL (mmol/L) | 1.13 (0.88–1.29) |
1.14 (0.92–1.34) |
0.305 | 1.03 (0.88–1.27) |
1.07 (0.76–1.33) |
0.663 |
| FPG (mmol/L) | 5.96 ± 1.75 | 5.46 ± 1.33 | 0.026 | 6.34 ± 1.90 | 4.73 ± 0.84 | 0.005 |
| FPI (mIU/L) | 9.83 (7.12–12.88) |
9.05 (6.78–12.28) |
0.510 | 9.68 (7.12–12.89) |
7.38 (5.54–11.04) |
0.039 |
| HOMA-β% | 86 (64–100) |
94 (77–111) |
0.017 | 83 (56–99) |
110 (84–131) |
0.003 |
| HOMA-S% | 77 (54–109) |
84 (61–118) |
0.262 | 79 (53–111) |
106 (72–142) |
0.025 |
| HOMA-IR | 1.2 (0.9–1.8) | 1.2 (0.9–1.7) | 0.322 | 1.3 (0.9–1.9) | 1.0 (0.8–1.4) | 0.037 |
| Cr (μmol/L) | 97.1 ± 40.7 | 95.3 ± 34.5 | 0.731 | 108.4 ± 44.0 | 113.3 ± 54.1 | 0.722 |
| Urea (mmol/L) | 5.99 ± 3.87 | 4.94 ± 1.82 | 0.028 | 7.36 ± 4.83 | 4.65 ± 1.94 | 0.058 |
| UA (μmol/L) | 307 (248–385) |
292 (233–341) |
0.090 | 319 (237–377) |
265 (217–352) |
0.247 |
| GFR (mL/min) | 89.5 (72.7–105.1) |
105.5 (91.8–117.2) |
0.004 | 64.2 (47.1–75.1) |
68.2 (56.9–82.1) |
0.475 |
L, Leu; V, Val; X/V: Leu/Val and Val/Val.
SBP: systolic blood pressure, DBP: diastolic blood pressure; BMI: body mass index; WC: waist circumference; TG: triglycerides; TC: total cholesterol; cHDL: high density lipoprotein cholesterol; cLDL: low density lipoprotein cholesterol; FPG: fasting plasma glucose; FPI: fasting plasma insulin; HOMA-β%: % β-cell function; HOMA-S%: % cell insulin sensitivity; HOMA-IR: insulin resistance; Cr: creatinine; UA: uric acid; GFR: glomerular filtration rate.