Table 8.
Anthropometric and biochemical characteristics of subjects within different groups according to the simultaneous existence of different genotypes of the Leu162Val PPARα and Pro12Ala PPARγ2 polymorphisms.
| L/L P/P (n = 329) | L/L X/A (n = 112) | P/P X/V (n = 40) |
X/A X/V (n = 41) |
P | |
|---|---|---|---|---|---|
| Age (years) | 41 (29–54) | 38 (28–49) | 38 (29–47) | 37 (28–49) | 0.298 |
| SBP (mmHg) | 125 (120–140) |
125 (120–140) |
125 (120–140) |
130 (120–135) |
0.284 |
| DBP (mmHg) | 80 (80–85) |
80 (80–85) |
80 (80–90) |
80 (75–80) |
0.216 |
| BMI (kg/m2) | 26.4 (24.4–28.2) |
24.9 (23.9–27.3) |
26.0 (24.5–29.1 |
27.1 (24.2–29.1) |
0.053 |
| WC (cm) | 93 (85–98) |
93 (79–96) |
93 (85–98) |
95 (88–98) |
0.052 |
| TG (mmol/L) | 1.53 ± 0.71 | 1.40 ± 0.75 | 1.38 ± 0.66 | 1.49 ± 0.79 | 0.289 |
| TC (mmol/L) | 4.73 (4.19–5.49) |
4.71 (4.12–5.25) |
4.73 (4.13–5.43) |
4.71 (4.03–5.35) |
0.645 |
| cLDL (mmol/L) | 3.13 (2.61–3.74) |
3.00 (2.62–3.65) |
3.06 (2.53–3.43) |
3.20 (2.53–3.72) |
0.578 |
| cHDL (mmol/L) | 1.09 (0.88–1.26) |
1.13 (0.92–1.39) |
1.17 (1.03–1.38) |
1.05 (0.84–1.32) |
0.028 |
| FPG (mmol/L) | 6.22 ± 1.80 | 5.55 ± 1.67 | 5.54 ± 1.32 | 5.18 ± 1.27 | <0.001 |
| FPI (mIU/L) | 10.36 (7.12–12.89) |
7.49 (6.02–10.93) |
8.92 (6.95–12.44) |
8.91 (6.16–11.26) |
<0.001 |
| HOMA-β% | 84 (59–99) |
94 (80–101) |
89 (74–115) |
99 (88–120) |
<0.001 |
| HOMA-S% | 73 (54–108) |
82 (58–117) |
85 (59–115) |
87 (67–128) |
<0.001 |
| HOMA-IR | 1.4 (0.9–1.8) |
1.2 (0.8–1.7) |
1.2 (0.9–1.7) |
1.1 (0.8–1.5) |
<0.001 |
| Cr (μmol/L) | 102.7 ± 46.2 | 90.4 ± 21.2 | 97.5 ± 42.9 | 98.4 ± 33.5 | 0.056 |
| Urea (mmol/L) | 6.61 ± 4.51 | 5.36 ± 4.54 | 5.15 ± 2.04 | 4.65 ± 1.59 | <0.001 |
| UA (μmol/L) | 313.0 (248.0–399.0) |
301.5 (237.5–360.2) |
304.0 (236.5–346.0) |
266.0 (225.0–331.0) |
0.017 |
| GFR (mL/min) | 87.9 (71.7–104.5) |
91.5 (71.5–109.4) |
101.5 (84.0–112.8) |
102.6 (72.6–118.2) |
0.011 |
P: Pro; A: Ala; L: Leu; V: Val; X/A: Pro/Ala and Ala/Ala; X/V: Leu/Val and Val/Val.
SBP: systolic blood pressure, DBP: diastolic blood pressure; BMI: body mass index; WC: waist circumference; TG: triglycerides; TC: total cholesterol; cHDL: high density lipoprotein cholesterol; cLDL: low density lipoprotein cholesterol; FPG: fasting plasma glucose; FPI: fasting plasma insulin; HOMA-β%: % β-cell function; HOMA-S%: % cell insulin sensitivity; HOMA-IR: insulin resistance; Cr: creatinine; UA: uric acid; GFR: glomerular filtration rate.