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(a)–(f) Hemodynamic parameters, (a) left ventricular systolic pressure (LVSP), (b) stroke volume (SV), (c) end-diastolic volume (EDV), (d) cardiac output (CO), (e) velocity of pressure increase (dP/dtmax), and (f) velocity of pressure decrease (dP/dtmin) monitored with a pressure-volume catheter 6 h after stimulation with the TLR9 agonist 1668-thioate. Bars of TLR9-D are striated (mean ± SEM; n = 8/group, *P < 0.05; *also indicates the significant group).
