Fig. 2 Representative sample results from one rabbit in each group show the effects of simvastatin on RhoA protein abundance and Rho GTPase activity. A) RhoA protein abundance measured by Western blot assay. B) RhoA protein abundance in the heart failure-with-simvastatin therapy (HF-SIM) group was significantly decreased in comparison with the heart-failure (HF) group. C) Representative sample results from one rabbit in each group show Rho GTPase activity measured via a guanosine 5′-triphosphate (GTP)-binding assay. D) Data from 10 rabbits show significantly decreased Rho GTPase activity in the HF-SIM group in comparison with the HF group.

*P <0.01 in comparison with the control group

**P <0.05 in comparison with the HF group

***P <0.01 in comparison with the HF group