. Author manuscript; available in PMC: 2014 Jan 1.

Published in final edited form as: Nat Rev Cancer. 2012 Dec 6;13(1):66–74. doi: 10.1038/nrc3420

Table 1.

Pancreatic cancer predisposition genes

Genes	Risk of pancreatic cancer
BRCA2	OR = 3.5 (95% CI = 1.87–6.58)
STK11	SIR = 132 (95% CI = 44–261)
PALB2	Increased
PRSS1 and SPINK1	SIR = 67 (95% CI = 8–80)
ATM	Increased
CDKN2A	SIR = 13–38
Unknown^*	SIR=6–32
Mismatch repair genes (MLH1, MSH2, MHS6 and PMS2)	No effect up to SIR = 8.6 (95% CI = 4.7–15.7)
BRCA1	No effect up to OR= 2.26 (95% CI = 1.26–4.06)

CI, confidence interval; OR, odds ratio; SIR, standardized incidence ratio.

Kindred with familial pancreatic cancer but without mutations in an established pancreatic cancer gene.