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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Cancer Res. 2012 Sep 20;72(19):4883–4889. doi: 10.1158/0008-5472.CAN-12-1223

Figure 1. Schematic depicting the contribution of bone marrow-derived cells to the formation of lung metastases from a primary breast tumor.

Figure 1

Bone marrow contributes F4/80+ macrophages that express EMT promoting factors in the primary tumor microenvironment, and Ly6C+ myeloid progenitor cells in the metastatic lungs that express versican to stimulate MET of disseminated tumor cells. EMT, epithelial to mesenchymal transition; MET, mesenchymal to epithelial transition.