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. Author manuscript; available in PMC: 2014 Apr 24.
Published in final edited form as: J Am Chem Soc. 2013 Apr 10;135(16):5978–5981. doi: 10.1021/ja401504w

Figure 3.

Figure 3

Models, from X-ray crystal structures, of the active sites of unliganded TbbTIM in the open form (cyan, PDB entry 5TIM) and the closed enzyme liganded by phosphoglycolohydroxamate (green, PDB entry 1TRD). Closure of loop 6 (residues 168 – 178) over bound ligand results in movement of the side chain of Ile-172 towards the side chain of Glu-167 and of this carboxylate side chain towards the side chain of Leu-232.