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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Clin Immunol. 2012 Nov 15;146(1):46–55. doi: 10.1016/j.clim.2012.11.003

Figure 1. Elevated frequencies of VH replacement products in IgH genes encoding anti-HIV antibodies.

Figure 1

A. Frequencies of VH replacement products in normal IgH genes (control, n=402), IgH genes derived from patients with RA (n=772), SLE (n=145), and HIV (n=422), and IgH genes encoding anti-HIV antibodies (n=100). B. Detailed comparison of the frequencies of VH replacement products in IgH genes encoding anti-gp41 antibodies (n=13), anti-gp120 V3 loop antibodies (n=42), anti-gp120 antibodies (n=17), CD4i antibodies (n=11), and PGT antibodies (n=17). Statistical significance against the frequency of VH replacement products in the normal peripheral B cells (control, 5.7%) were determined by two tailed Chi-square test with Yates' correction. Significant difference (P < 0.05) is indicated by (*) and extremely significant difference (P < 0.0001) is indicated by (**).