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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Clin Immunol. 2012 Nov 15;146(1):46–55. doi: 10.1016/j.clim.2012.11.003

Figure 2. CD4i antibodies encoded by VH replacement products have long CDR3 regions enriched with negatively charged amino acid residues.

Figure 2

A. VH replacement products encoded CD4i antibodies have long CDR3 compared with those from 4713 normal IgH sequences [30]. Histogram shows the distribution of IgH genes according to their CDR3 lengths. B. VH replacement products encoded CD4i antibodies have more negatively charged amino acid residues within their CDR3 regions. The usage of different amino acids in the CDR3 regions of VH replacement products encoding CD4i antibodies and in 4713 normal IgH sequences.