Table 3.
Multivariate analysis of baseline and serial CA features after relapse (using indicators of CA status at baseline, between baseline and first transplant, and between first transplant and relapse) associated with post-relapse survival
| Variable | N/N (%) | HR (95% CI) | P-value |
|---|---|---|---|
| CA at baseline | 159/366 (43) | 1.35 (1.01, 1.81) | 0.044 |
| CA between baseline and first transplant |
73/366 (20) | 1.08 (0.77, 1.52) | 0.665 |
| CA at relapse | 107/366 (29) | 2.47 (1.84, 3.33) | <0.001 |
| TT protocols | 245/366 (67) | 0.66 (0.50, 0.87) | 0.003 |
| Creatinine≥2.0 mg per 100 ml |
10/366 (3) | 2.42 (1.26, 4.66) | 0.008 |
Abbreviations: CA, cytogenetic abnormalities; CI, confidence interval; HR, hazard ratio; TT, total therapy.