Fig. 1.
Correlation of spontaneous activity, serum CRP levels, and BDNF and ARC expressions in motor cortex of 11 rhesus monkeys. a Monkey activity levels were measured in counts/day, CRP in milligrams per liter (mg/L), BDNF and ARC in threshold cycle difference relative to β-actin (ΔCt). b Scatter plot of ARC expression (X-axis) and BDNF expression (Y-axis) for the motor cortex of the 11 monkeys included in the study. Solid line trend line. Note the correlation between the expression of these two genes. c X-axis denotes gene expression level measured by qPCR for ARC (blue diamonds) and BDNF (red squares) for the 11 monkeys, while Y-axis represent end of experiment spontaneous activity counts. Solid lines trend lines. Note that both ARC and BDNF expressions are significantly correlated with spontaneous activity in the studied monkeys. d Scatter plot of serum CRP levels (X-axis) versus spontaneous activity (Y-axis). Each symbol represents a single experimental animal. Note the inverse correlation between spontaneous activity and serum CRP levels. e Correlation of serum CRP level and ARC and BDNF expressions in the motor cortex. Figure layout similar to that of c. Note the high inverse correlation between the ARC–CRP and BDNF–CRP measurements