Table 6.
Information on percentage of donors, and their T cell response and DRB MHC type of donors responding to predicted and conserved T cell epitopes
| HA epitope and position | % donors responding to each epitope (responded donors/total donor | Total responding T cells | Mean number of responding T cells | DRB1 alleles of donors | Alleles of other DR haplotypes of donors |
|---|---|---|---|---|---|
| STVASSLVLLVSLGA |
85 (12/14) |
376.5 |
31.4 |
DRB1*03, DRB1*04, |
DRB3*52, |
| (518–532) |
|
|
|
DRB1*07, DRB1*08, |
DRB4*53, |
| |
|
|
|
DRB1*13, DRB1*14, |
DRB5*51 |
| |
|
|
|
DRB1*15, DRB1*17 |
|
| GAISFWMCSNGSLQC |
71 (9/14) |
243.5 |
27.1 |
DRB1*03, DRB1*04, |
DRB3*52, |
| (531–545) |
|
|
|
DRB1*07, DRB1*08, |
DRB4*53, |
| |
|
|
|
DRB1*13, DRB1*15, |
DRB5*51 |
| |
|
|
|
DRB1*17 |
|
| YQILAIYSTVASSLV |
43 (6/14) |
144.5 |
24.1 |
DRB1*04, DRB1*07, |
DRB3*52, |
| (511–525) |
|
|
|
DRB1*08, DRB1*13, |
DRB4*53, |
| |
|
|
|
DRB1*15, DRB1*17 |
DRB5*51 |
| IYQILAIYSTVASSL |
36 (5/14) |
73.5 |
14.7 |
DRB1*07, DRB1*08, |
DRB3*52, |
| (510–524) |
|
|
|
DRB1*13, DRB1*15, |
DRB4*53, |
| |
|
|
|
DRB1*17 |
DRB5*51 |
| NKVNSVIEKMNTQFT |
29 (4/14) |
66.0 |
16.5 |
DRB1*04, DRB1*07, |
DRB3*52, |
| (377–391) |
|
|
|
DRB1*08, DRB1*13, |
DRB4*53, |
| |
|
|
|
DRB1*15, DRB1*17 |
DRB5*51 |
| RNIPSIQSRGLFGAI |
29 (4/14) |
38.0 |
12.7 |
DRB1*03, DRB1*04, |
DRB3*52, |
| (319–333) |
|
|
|
DRB1*07, DRB1*13, |
DRB4*53 |
| |
|
|
|
DRB1*17 |
|
| LVLLENERTLDYHDS |
21 (3/14) |
33.0 |
11.0 |
DRB1*07,DRB1*13, |
DRB3*52, |
| (426–440) |
|
|
|
DRB1*17 |
DRB4*53 |
| YNAELLVLLENERTL |
21 (3/14) |
58.0 |
19.3 |
DRB1*07,DRB1*13, |
DRB3*52, |
| (421–435) |
|
|
|
DRB1*17 |
DRB4*53 |
| ATGLRNIPSIQSRGL |
21 (3/14) |
45.5 |
15.2 |
DRB1*04, DRB1*07, |
DRB3*52, |
| (315–329) |
|
|
|
DRB1*13, DRB1*17 |
DRB4*53 |
| DGFLDIWTYNAELLV |
14 (2/14) |
25.5 |
12.8 |
DRB1*03, DRB1*07, |
DRB3*52, |
| (413–427) |
|
|
|
DRB1*13, |
DRB4*53 |
| QLSSVSSFERFEIFP |
14 (2/14) |
25.5 |
12.8 |
DRB1*04, DRB1*07, |
DRB3*52, |
| (104–119) |
|
|
|
DRB1*13 |
DRB4*53 |
| VLEKNVTVTHSVNLL |
7 (1/14) |
11.5 |
11.5 |
DRB1*04 |
DRB3*52, |
| (19–33) |
|
|
|
|
DRB4*53 |
| EELREQLSSVSSFER |
No response |
- |
- |
- |
- |
| (99–113) |