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. 2013 May 9;9(5):e1003341. doi: 10.1371/journal.ppat.1003341

Figure 10. Model for EBV modulation of cytotoxic T-cell and natural killer cell function in tumor microenvironment.

Figure 10

EBV infected gastric carcinoma cells recruit cytolytic immune cells such as T-cell and natural killer cells via unclear mechanisms. In addition, these cells induce an increase in interferon-gamma (IFNG) via EBERs and possibly BamHI A transcripts. Increased IFNG results in increased IDO1 resulting in depleted tryptophan. Depleted tryptophan results in T-cell and natural killer cell inhibition.