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. 2013 May 9;8(5):e62804. doi: 10.1371/journal.pone.0062804

Table 2. Regional Tissue and Structural Brain Volumes (mL) for the Preterm and Term Cohorts.

Region	Preterm Unadjusted Mean Volume(N = 122)	Term UnadjustedMean Volume(N = 16)	Group Difference in Means Adjusted forPMA at MRI (95% CI)	Relative Percent Difference	Group Difference in Means Adjusted for PMA at MRI & TCV(95% CI)	Relative PercentDifference	Group Difference in Means Adjusted for PMA at MRI & Total Brain Tissue (95% CI)	Relative Percent Difference
Total brain tissue	270.28±41.50	316.82±35.52	−42.79 (−62.85, −22.73)^**	−14.3%^**	−24.29 (−31.68, −16.90)^**	−8.1%^**	NA	NA
Cerebral white matter	124.06±18.80	146.61±16.44	−21.69 (−31.33, −12.04)^**	−15.5%^**	−13.75 (−18.85, −8.66)^**	−9.9%^**	−2.45 (−6.10, 1.20)	−1.9%
WMH ratio^a,b	0.01 (0.00, 0.03)	0.01 (0.00, 0.02)	0.00 (−0.01, 0.01)	−3.6%	0.00 (−0.01, 0.01)	−17.4%	0.00 (−0.01, 0.01)	−0.1%
Cortical gray matter	105.11±19.12	119.79±16.08	−12.32 (−20.87, −3.77)^*	−10.5%^*	−5.41 (−9.33, −1.48)^*	−4.8%^*	4.54 (1.06, 8.02)	4.4%
Cerebro-spinal fluid^a	78.91 (67.56, 94.49)	70.37 (55.82, 79.09)	18.11 (3.98, 34.65)^**	27.8%^**	20.61 (12.59, 29.52)^**	34.4%^**	25.36 (12.09, 40.90)^**	43.2%^**
Cerebellum	16.06±4.23	19.63±2.51	−3.18 (−5.16, −1.20)^*	−17.3%^*	−1.59 (−2.81, −0.37)	−8.7%	−0.014 (−1.41, 1.38)	−0.1%
Corpus callosum	1.02±0.30	1.55±0.35	−0.54 (−0.70, −0.38)^**	−34.8%^**	−0.43 (−0.57, −0.28)^**	−29.4%^**	−0.35 (−0.49, −0.21)^**	−25.1%^**
Hippocampi	1.34±0.25	1.52±0.25	−0.18 (−0.31, −0.05)^*	−11.7%^*	−0.11 (−0.23, 0.001)	−7.7%	−0.014 (−0.13, 0.10)	−1.1%
Caudate/accumbens^a	3.15 (2.86, 3.59)	3.91 (3.57, 4.51)	−0.84 (−1.14, −0.53)^**	−21.3%^**	−0.58 (−0.79, −0.36)^**	−15.3%^**	−0.28 (−0.48, 0.06)	−8.0%
Thalamus	7.70±1.26	9.12±1.22	−1.37 (−2.03, −0.72)^**	−15.1%^**	−0.89 (−1.31, −0.47)^**	−10.2%^**	−0.18 (−0.54, 0.18)	−2.2%
Lenticular nuclei	5.43±0.85	6.69±0.75	−1.25 (−1.69, −0.80)^**	−18.7%^**	−0.96 (−1.29, −0.62)^**	−15.2%^**	−0.54 (−0.85, −0.22)^**	−8.9%^**
Amygdalae^a	0.55 (0.45, 0.66)	0.66 (0.61, 0.74)	−0.13 (−0.20, −0.04)^*	−18.5%^*	−0.09 (−0.15, −0.01)	−13.2%	−0.03 (−0.09, 0.05)	−4.6%
Brain stem	5.77±0.82	7.18±0.66	−1.36 (−1.76, −0.95)^**	−19.0%^**	−1.08 (−1.35, −0.81)^**	−15.6%^**	−0.65 (−0.90, −0.40)^**	−10.0%^**
Total cranial volume	357.27±59.58	387.08±39.50	−23.62 (−51.07, 3.83)	−6.2%	N/A	N/A	N/A	N/A

Plus-minus values are mean±SD.

^*

p<0.01;

^**

p<0.001.

^a

Median (IQR).

^b

Reported as a ratio of WMH to cerebral white matter volume.