Table 3. Clinical factors significantly associated with total brain tissue volume (mL) and WMH in multivariable regression models.
| Brain Region | Antecedent | Model F statistic/Adjusted R2 | Coefficient (95% CI) –Adjusted by PMA at MRI | Model F statistic/Adjusted R2 | Coefficient (95% CI) – Adjusted by TCVand PMA at MRI | Model F statistic/Adjusted R2 | Coefficient (95% CI) – Adjusted by Total Brain Tissue Volume and PMA at MRI |
| Total brain tissue | Birth weight | 18.87**/0.47 | 10.65 (6.50, 14.80)** | 108.09**/0.86 | NS | NA | NA |
| SGA status | −22.99 (−36.72, −9.26)* | NS | NA | ||||
| Duration parenteralnutrition (per 10d) | −3.12 (−5.43, −0.80)* | NS | NA | ||||
| Apnea/Caffeine therapy | −33.35 (−51.75, −14.95)** | NS | NA | ||||
| Seizures/Anticon-vulsant therapy | −37.59 (−63.93, −11.25)* | −17.84 (−31.60, −4.08)† | NA | ||||
| WM injury on cranial US | NS | −22.72 (−33.31, −13.13)** | NA | ||||
| Pulmonary hemorrhage | NS | −37.78 (−57.18, −18.38)** | NA | ||||
| WMHa | GI surgery | 5.24**/NV | 8.08 (2.28, 14.56)* | 5.37*/NV | 7.57 (1.89, 13.89)* | 4.17*/NV | 8.25 (2.35, 14.86)* |
| Severe ROP surgery | 5.73 (2.01, 9.75)* | 6.34 (2.51, 10.48)* | 6.04 (2.14, 10.28)* |
†
p = 0.01 *p<0.01 **p<0.001.
NS – not significant; NA – not applicable; NV – no value (because utilized robust regression).
a
Reported as a percentage mean difference in WMH to cerebral white matter volume (95% CI).