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. 2013 May 9;8(5):e61023. doi: 10.1371/journal.pone.0061023

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© 2013 Parker et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Values are expressed as mean (error bar represents 1 SD) (straight line depicts analysis over Time; barred line depicts analysis between Clinical (Normal versus Asthmatic)). (A) TEER values between PBEC(N) and PBEC(A) displayed no significant differences under unstimulated conditions over time, between clinical phenotype (Normal versus Asthmatic) or by interaction (ie/. does PBEC(A) behave differently from PBEC(N) over time). (B) TEER values under stimulation with IL-9 demonstrated a significant reduction between PBEC(N) and PBEC(A) over time (Time p = 0.04) and between clinical (Clinical p = 0.03), however not by interaction (Interaction p = 0.09). (C) TEER values under stimulation with IL-9/IL-13 combination demonstrated a significant reduction between PBEC(N) and PBEC(A) over time (Time p = 0.02) and between clinical (Clinical p = 0.005), however not by interaction (Interaction p = 0.7). (D) TEER values under stimulation with IL-13 demonstrated a significant reduction between PBEC(N) and PBEC(A) over time (Time p = 0.01) and between clinical (Clinical p = 0.0004), however not by interaction (Interaction p = 0.4).