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. Author manuscript; available in PMC: 2013 May 9.
Published in final edited form as: Exp Neurol. 2011 May 18;230(2):302–310. doi: 10.1016/j.expneurol.2011.05.009

Figure 5. Effect of prolyl hydroxylase inhibition on ischemia-reperfusion injury.

Figure 5

All neurons were cultured under ambient conditions (20% O2), and treated with DMOG (25 μM) from day 0 in culture. Simulated ischemia was applied for 60 min on day 8–10, without (‘IR’) or with added glutamate (‘IR+Glu’), and relative survival compared at 2, 24, and 72 hours. DMOG pre-treatment completely blocked neuronal death during reperfusion. DMOG alone produced no change in relative survival (n = 5, mean ± S.D.; * treatment groups different, p < 0.05 by two-way ANOVA; effects of reperfusion time were not significant).