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. Author manuscript; available in PMC: 2013 May 9.
Published in final edited form as: Hematology Am Soc Hematol Educ Program. 2010;2010:403–408. doi: 10.1182/asheducation-2010.1.403

Figure 1. Inhibition of the arachidonic acid pathway by several drugs.

Figure 1

Steroids inhibit production of arachidonic acid, thereby blocking synthesis of leukotrienes and prostaglandins. Ketoprophen is believed to block production of 5-lipooxygenase and cyclooxygenase. Aspirin and nonsteroidal anti-inflammatory drugs block conversion of cyclo-oxygenase to prostaglandins and thromboxane A2. Trilisate blocks production of prostagandins (PG) E2 and F2, but not I2 or thromboxane A2. © 2001 D.J. Wilkie, used with permission.