Table 2. Parameter estimates of the risk equations for first and second AMI and HF events.

		AMI		HF
		First event	Second event	First event	Second event
N		18526	2019	19051	1646
Female		−0.2318	0.1887a	−0.4697	−0.1224
Age at diagnosis		0.0541	0.0254	0.0896	0.0207
HbA1c	Continuous	0.0829			0.0579
	≤7b			−0.2424
	>7b			0.1864
Systolic BP	Continuous	0.0079
	≤140b			−0.0186
	>140b			0.0050
LDL		0.1161	0.1745
TC/HDL		0.1712		0.1146
BMI				0.0631
Macroalbuminuria		0.5719	0.5478	0.7841
Microalbuminuria		0.2176		0.6932
Smoking		0.4938	0.2987	0.3402	0.3402
AMI historyc		0.7469	0.7704
HF historyc				1.6988
HF before first eventd		0.6151	0.3386
Duration at first event			0.0566		0.0268
Female * LDL			−0.2155
Time since first event >1 year					−1.6960
Female * time since diagnosis				0.0172
Microalbuminuria * time since diagnosis				−0.0202
Smoking * time since first event >1 year					−0.4124
Constant		−7.8187	−2.5755	−5.3260	0.2870
P (shape parameter)		2.0537	0.7916	2.5986	0.8149

All covariates are significant at the 5% level.

Weibull proportional hazards regression with the Prentice, Williams, and Peterson gap time model was used for estimation.

Abbreviations: HF, heart failure; AMI, acute myocardial infarction; TC/HDL, total to HDL cholesterol ratio.

^a. Significant at the 10% level, but significant interaction with LDL;

^b. applied as splines in the equation;

^c. history of event before diagnosis of type 2 diabetes;

^d. HF before first AMI.