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. 2013 May 9;8(5):e62272. doi: 10.1371/journal.pone.0062272

Table 1. Structure predictions for domain families with majority of members possessing the HExxH motif.

Query % of domain family members possessing the HExxH motif FFAS Z-score % sequence identity top FFAS hit First prediction of a zincin-like structure
CLCA_N (PF08434) Calcium-activated chloride channel 72 −6,3 11 d1kufa_ d.92.1.9 (A:) Snake venom metalloprotease [Trimeresurus mucrosquamatus], atrolysin E [28]
SprA-related (PF12118) SprA-related family 95 −7,7 11 PF05569.4; Q8RPJ4_DESHA/7–280; BlaR1 peptidase M56 this article
FA_desaturase (PF00487) Fatty acid desaturase 37 −8,4 16 d1k7ia2 d.92.1.6 (A:18–258) Metalloprotease [Erwinia chrysanthemi] this article
Metallopep (PF12044) Putative peptidase family 87 −12,3 20 d1c7ka_ d.92.1.1 (A:) Zinc protease [Streptomyces caespitosus] Pfam annotation
MtfA (PF06167) Phosphoenolpyruvate:glucose-phosphotransferase regulator 100 −43,9 11 d1j7na2 d.92.1.14 (A:551–773) Anthrax toxin lethal factor, N- and C-terminal domains [Bacillus anthracis] [7]
DUF2248 (PF10005) Uncharacterized protein conserved in bacteria 100 −13,9 10 d1j7na2 d.92.1.14 (A:551–773) Anthrax toxin lethal factor, N- and C-terminal domains [Bacillus anthracis] this article
DUF2265 (PF10023) Predicted aminopeptidase 100 −7,7 11 d3b7sa3 d.92.1.13 (A:209–460) Leukotriene A4 hydrolase catalytic domain [Homo sapiens] Pfam annotation
DUF462 (PF04315) Protein of unknown function 100 −7 13 d1j7na2 d.92.1.14 (A:551–773) Anthrax toxin lethal factor, N- and C-terminal domains [Bacillus anthracis] this article
DUF922 (PF06037) Bacterial protein of unknown function 100 −7,4 10 d1kjpa d.92.1.2 (A:) Thermolysin [Bacillus thermoproteolyticus] this article
DUF3267 (PF11667) Protein of unknown function 83 −10,8 12 d1asta_ d.92.1.8 (A:) Astacin [Astacus astacus)] this article
DUF1025 (PF06262) Domain of unknown function 76 −43,4 34 d3e11a1 d.92.1.17 (A:1–113) Uncharacterized protein Acel_2062 [Acidothermus cellulolyticus] this article
DUF2342 (PF10103) Uncharacterized conserved protein 43 −93,8 19 d3cmna1 d.92.1.16 (A:43–391) Uncharacterized protein Caur0242 [Chloroflexus aurantiacus] this article