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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Placenta. 2012 Dec 13;34 Suppl:S40–S45. doi: 10.1016/j.placenta.2012.11.024

Table 1. Effects of globular and full-length adiponectin in primary human trophoblasts.

The table summarizes findings in Jones et al. [33].

Biological Effect Globular Adiponectin Full-Length Adiponectin
Cell Signaling
Insulin-stimulated IRS-1 phosphorylation (Tyr612) ? ↓
Insulin-stimulated Akt phosphorylation (Thr308 and Ser473) ↔ ↓
AMPKα phosphorylation (Thr172) ↑ ↔
PPARα phosphorylation (Ser21) ? ↑
p38 MAPK phosphorylation (Thr180/Tyr182) ? ↑*
Inflammation
IL-6 secretion ↑ ↓
TNF-α secretion ↑ ↑
Nutrient Transport
Basal System A activity ↑ ↔
Insulin-stimulated System A activity ↔ ↓
Basal System L activity ↔ ↔
Basal SNAT2 protein expression ↑ ↔
Insulin stimulated SNAT2 protein expression ↔ ↓

AMPK, AMP-activated protein kinase; fADN, full-length adiponectin; gADN, globular adiponectin; IL-6, interleukin-6; IRS-1, insulin-receptor substrate-1; p38 MAPK, p38 mitogen-activated protein kinase; PPARα, peroxisome proliferator-activated receptor alpha; Thr, Threonine; TNF-α, tumor necrosis factor alpha; Tyr, tyrosine; Ser, serine; ? unknown; * unpublished observation; ↔ no change; ↑ increases; ↓ decreases.